NSW Ambulance responded to reports of an accident on the Princes Highway, Falls Creek near Blackbutt Range Road just after 9:45am Friday morning.

Four ambulance crews and the Toll Ambulance Rescue Helicopter were dispatched to the crash site.

Upon arrival emergency services found two patients trapped in their vehicles.

Paramedics treated a man believed to be in his 30s for suspected pelvic and lower leg injuries.

He was transported to Wollongong Hospital in a serious condition

The woman suffered suspected chest and lower leg injuries and was airlifted to St George Hospital by the helicopter which landed at the nearby Log Cabin service station, in a serious condition

NSW Ambulance Inspector Fay Stockman praised emergency services involved in the incident.

"Fire and Rescue NSW were wonderful in assisting with the extrication of both patients from their vehicles," Insp Stockman said.

"It was a huge team effort from all emergency services on scene.

"We ask that you take extra care while out on the roads and remember how dangerous driving a motor vehicle can be."

Traffic in both directions of the highway was affected for a short time before a contraflow could be put in place around the accident scene.

The highway is now fully reopen.

Earlier:

11am: Two cars and truck collision at Falls Creek

Emergency Services are on the scene of crash between two cars and a truck on the Princes Highway south of Nowra.

The accident happened south of Falls Creek near the intersection of Blackbutt Range Road and the highway just before 10am.

Four NSW Ambulance crews are at the crash site, with early reports of two people being trapped by confinement as a result of the accident.

Both have now been released.

The Toll NSW Ambulance rescue helicopter has been tasked to the scene and will be landing at the Log Cabin, just north of the crash scene, with at least one patient at this stage to be airlifted.

NSW Ambulance media said a man in his 30s is being treated for chest and pelvic injuries, while a woman believed to be in her 60s has suspected lower leg injuries.

Traffic was initially affected in both directions on the highway but a contraflow has been put in place around the crash site to allow highway traffic movement.

Traffic around the area is extremely heavy and motorists are advised to allow extra travel time, reduce your speed, exercise caution around the location.