Operation Chrome, a state-wide regional operation being conducted in Southern, Northern and Western regions and starts tomorrow Friday May 17 and ends on Saturday May 18.

The operation will involve police from all districts within the Southern region, working alongside officers from the Traffic and Highway Patrol Command.

Police will be targeting poor driving behaviours on rural roads - including speeding, drink and drug-driving, not wearing seatbelts, using a mobile phone behind the wheel and fatigue.

Drivers and riders should expect to see more police on rural roads and highways over the weekend.

Assistant Commissioner Peter Barrie, Commander of the Southern Region, said reducing rural road trauma is a top priority for the entire region.

"During Operation Chrome, it won't just be officers from the Traffic and Highway Patrol that will be tasked with keeping everyone safe on our roads," he said.

"If you are on the road and doing something wrong, you can expect to be stopped by police in an unmarked car, general duties police, or one of our highway patrol officers.

"Our main aim is to stop fatal crashes before they happen. Road safety is everyone's responsibility.

"If everyone takes personal responsibility for their actions, it will save lives. It's that simple."

Inspector Scott Nelson, Southern Region Traffic Tactician said if everyone does their part, the roads will be a safer place.

"Sadly, we have already lost 26 lives on Southern NSW roads this year. Most crashes happen in rural and regional areas, which is why you will see us in numbers this weekend," Insp Nelson said.

"We make no apologies for taking licences away from anyone who puts themselves and other road users at risk through dangerous driving behaviours," he added.