Kiama's Mitch Rein has been recalled by the Gold Coast Titans for their must-win round 24 fixture with the Newcastle Knights.
Rein, who missed the club's 34-20 loss to Melbourne, will start at hooker for the Titans at Sunshine Coast Stadium on Friday.
This fixture will also pit two former Group Seven players turn NRL coaches, Titans' Justin Holbrook (Milton-Ulladulla) and Knights' Adam O'Brien (Knights), up against one another.
The Thursday night clash will open the penultimate round of the 2021 NRL season, set to feature numerous South Coast talents.
Game two of the round, set to be played at Mackay's BB Print Stadium, will see the Warriors take on the Raiders.
New Zealand has named Shellharbour's Euan Aitken in the back-row, while Milton's Jack Murchie is on the extended bench.
Later that night, old rivals the Roosters and Rabbitohs will do battle at Suncorp Stadium, with Albion Park-Oak Flats' Drew Hutchison and Nowra-born Cody Walker starting at five-eighth for the two respective sides.
Saturday's three-game slate will kick-off at Rockhampton's Browne Park, with St George Illawarra locking horns with North Queensland.
The Red V has named Gerringong's Tariq Sims in the back-row and as skipper for the second straight week - with fellow Lions product Jackson Ford on the interchange bench.
South Coast Black Cockatoos' Jayden Sullivan will start at hooker for he Dragons.
Next up is the Cronulla-Sutherland and Brisbane fixture at Suncorp Stadium.
Pambula-born Jack Williams will start at lock for the Sharks, while Narooma's Teig Wilton in on the interchange, with Moruya's Rhys Kennedy on the Broncos' four-man bench.
Saturday's action will wrap up at Suncorp Stadium when the Storm chase their record-setting 20th straight regular-season win against the Eels.
Former Shellharbour Shark Chris Lewis is the Storm's starting lock, with Bega's Dale Finucane rested for the second straight week due to concussion.
The Eels will be coached by former Batemans Bay Tiger Brad Arthur.
On Sunday, Gerringong's Reuben Garrick, who needs 15 points to break Bulldogs' Hazem El Masri regular season point-scoring record (288), will start in the win for Manly-Warringah against Canterbury-Bankstown at Redcliffe's Moreton Daily Stadium.
The latter will be without Tathra's Adam Elliott, who has been stood down by the club for the remainder of the season as the NRL Integrity Unit investigates an alleged incident at a Gold Coast restaurant over the weekend.
The final match will Penrith take on Wests Tigers in the second part of the Redcliffe double-header.