Police said officers attached to the South Coast Police District commenced an investigation into the supply of methylamphetamine in the state's south last month.

Detectives, with the help of the Drug and Firearm Squad's chemical operations team, the Public Order Riot Squad, and the Dog Squad, searched a house at about 5.45pm yesterday.

During the search, detectives allegedly located a clandestine laboratory and allegedly seized items consistent with the manufacture of prohibited drugs, including two kilograms of pseudoephedrine, a drug used to relieve nasal congestion.

A 48-year-old man was arrested at the scene and charged with manufacturing a prohibited drug at the commercial quantity and possession of a precursor chemical.

He was refused bail to appear in Nowra Local Court on Thursday, July 1.

Another 48-year-old man was arrested at an address in Caringbah and charged with manufacturing a prohibited drug at the commercial quantity and possessing a precursor chemical.

He was also refused bail to appear before Sutherland Local Court on Thursday, July 1.

After further investigation, police stopped a vehicle on Owen Street, Huskisson, at about 11pm and allegedly found 200mL of GBL, more than $3000 in cash, and four mobile phones.

Detectives then searched a home in Huskisson, where they allegedly found and seized an indictable quantity of methylamphetamine and another $4000 in cash.

A 38-year-old woman and 35-year-old man were arrested at the Hawke Street address and charged with two counts of supplying a prohibited drug, possessing a prohibited drug, and dealing with the proceeds of crime.

They were also refused bail to appear before Nowra Local Court on July 1.

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