The coach insists they won't let bulk injuries to key players destroy their season.

The Giants play Collingwood on Saturday night, the side they valiantly upset to make that decider before Richmond upstaged them on the Tigers' home track a week later.

Much has changed since, with the Giants 0-3 and missing a host of key players to injury.

Captain Stephen Coniglio (ankle), Matt de Boer (hamstring) and Phil Davis (calf) were the latest to succumb to injury in last week's loss to Melbourne, while Matt Flynn is being managed.

"Expectations are always going to be there ... (but) we know the situation we're in and we've probably got nine or 10 of our best 22 out and a lot of those are mature players," Cameron said.

"So we're being really honest with ourselves where we're at.

"It's next man up (approach) and we've got that situation this weekend; we're treating this is as a really great moment, great opportunity for our footy club.

"They can't wait to get on the plane, take another step forward, play a good strong brand and take it right up to Collingwood."

Drafted at pick 15 last year, Conor Stone will be the Giants' third debutant of the season and is set to wear the departed Jeremy Cameron's No.18 jersey and provide punch on the wing.

Jeremy Finlayson, Shane Mumford, and Jake Riccardi all return to the side.

Collingwood have included Beau McCreery in the 22 after he was an unused sub in last week's after-the-siren loss to Brisbane.

Toby Greene will captain GWS in Coniglio's absence and has been encouraged to "just be Toby".

"Right now I see a really good balance of having the side underneath him, playing good footy, leading from the front and passing on some of the experiences of his early years when he was a young fella at the Giants," Cameron said.

"I don't want him to overstretch and look for things that are not there; he needs to be himself."

Meanwhile former Fremantle and Melbourne key forward Jesse Hogan (quad) will play a practice match for the Giants on Friday and is eyeing an AFL return within the next few weeks.

"He's in a good headspace, done his rehab well and he's fit but he'll need that footy fitness starting from today," Cameron said.

"Whether that takes a couple of weeks we don't know, but we're looking forward to seeing what he does."

Australian Associated Press