Jamie Vardy scored a hat-trick to see Leicester come from behind to thrash Manchester City 5-2 in the Premier League at Etihad Stadium.
Riyad Mahrez's strike in the fourth minute put City ahead against his former club before Vardy tucked in Timothy Castagne's cross to level the scores at half-time.
The former England striker was fouled twice in the City box before the hour mark and converted two penalties as a result for his hat-trick.
James Maddison added a stunning fourth Leicester goal and after defender Nathan Ake scored his first in a City shirt, Youri Tielemens converted a third penalty two minutes from the end.
Newcastle United were handed a fortunate 1-1 draw at Tottenham Hotspur after a controversial injury-time penalty decision by the video assistant referee (VAR).
Patrick Bamford scored a late winner as promoted Leeds United took Yorkshire regional honours with a 1-0 win at Sheffield United.
The striker headed the only goal after 88 minutes and Leeds held on for their second victory in their first three matches back in the top-flight.
"The second half was a lot better for us," said Leeds coach Marcelo Bielsa. "I think we created a small but just difference to deserve the victory."
Bamford is the first Leeds player since Mick Jones in 1968 to score in all opening three matches of a top-flight season for the club.
Pep Guardiola admitted in midweek his side is struggling with injuries after revealing he only has 13 senior players to choose from, with two strikers in Gabriel Jesus and Sergio Aguero sidelined.
City have not lost an opening home game for 25 years since 1989 and not conceded five goals at home since they played Arsenal in February 2003.
Leicester also became the first side to score three penalties in a Premier League game.
At the Tottenham Hotspur Stadium, Spurs dominated the first half and led through Lucas Moura's 25th-minute goal after the Brazilian midfielder finished off Harry Kane's low cross.
But in the 97th minute, referee Peter Bankes consulted the pitchside monitor after the ball hit Tottenham's defender Eric Dier's arm during an aerial challenge and pointed to the penalty spot.
Tottenham goalkeeper Hugo Lloris almost pulled off a save but the strike from Callum Wilson was too powerful to keep out.
Jose Mourinho, the Tottenham manager, stormed down the tunnel in disgust and goalkeeping coach Nuno Santos was shown a red card for confronting the referee at the final whistle.
The Portuguese boss refused to comment on the incident because of fearing a fine from the Football Association (FA).
"We lost two points but I am not going to comment," he told Sky Sports.
"I react during the game but the game is finished. If I want to give some money, I give to charities and not the FA."
In the late game Jarrod Bowen scored twice as West Ham collected their first points of the Premier League season by overwhelming Wolverhampton in a 4-0 win.
An own-goal by Raul Jimenez, who unwittingly deflected in Tomas Soucek's glancing header from a corner, and Sebastien Haller's stoppage-time header capped a woeful night for Wolves at the Olympic Stadium as they lost for the second time in a week.
Australian Associated Press