A truck and a car have collided near the intersection of the Princes Highway and Turpentine Road at Tomerong.
According to police at 9.15am a truck, carrying gravel, was travelling east on Turpentine Road when it hit Mercedes sedan travelling south on the Princes Highway.
The truck male driver was taken to Shoalhaven Hospital. The male driver of sedan was taken by ambulance helicopter to St George Hospital in Sydney.
The highway is closed in both directions. Northbound is being diverted to Island Point Road, Grange Road and Hawken Road. Southbound traffic is being diverted at Hawken, Grange and Island Point roads.
The highway is expected to reopen 11am to 11.30am.