As tens of thousands of joggers descend on Sydney, motorists will be the ones not having a good run on the roads on Sunday.
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More than 34,000 people are expected to compete in the Sydney Running Festival, which will see major road closures that stretch from the east to the west of the CBD.
The Sydney Harbour Bridge and its approaches, the Cahill Expressway and Western Distributor, will be closed from 4am, and delays can be expected through the Sydney Harbour Tunnel.
Organisers are also warning drivers to avoids swathes of the CBD including inner Sydney, Darlinghurst, Moore Park and Pyrmont.
Key roads affected include: Bridge Street, College Street, Liverpool Street, Hickson Road, Macquarie Street, Oxford Street, Sussex Street, Phillip Street, Flinders Street, Pyrmont Street and Moore Park Road.
Special event clearways, which also apply to drivers with local parking permits, will be scattered across the city between 1am and 1.30pm.
The event is made up of four races - the Half Marathon, the Sydney Marathon, the Bridge Run and the Family Fun Run - which start from 6am to 9am at Bradfield Park in Milson's Point.
The longer routes cross the Sydney Harbour Bridge, wind through the CBD, and finish at the Sydney Opera House.
Superintendent Allan Sicard said roads would be progressively re-opened once the course was cleared. Drivers should be able to cross the Harbour Bridge from 11am, with other roads expected to be re-opened by 1.30pm.
"Runners and spectators are set to enjoy one of the most scenic courses in the world this weekend, and we've been working hard to make sure the route and its surrounds are safe for everyone coming into the CBD this Sunday," Superintendent Sicard said.
"Our best advice for motorists and residents is to plan their trip ahead of time and if you must travel into the Sydney CBD, expect significant delays and please exercise patience."
Participants and volunteers heading to or leaving the event can use public transport for free by showing their competition bib or volunteer card.
The closest train station to the starting line is Milsons Point, where extra services will be in place, and Circular Quay station is nearest the finishing line.
While buses will be affected by the road closures, there will be extra morning services and they will use additional routes and temporary bus stops.
For more information on public transport options visit Transport for NSWs website or the Sydney Running Festival's website.
