NOWRA Police have seized more 150 plants, believed to be cannabis, from a property in Worrigee.
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Although yet to be positively identified, it is believed the crop, if cannabis could have a street value of between $300,000 and $380,000.
Police said the plants were being grown hydroponically.
Officers from the Target Action Group (TAG) activated a search warrant on a Worrigee home shortly after 1pm on Monday, discovering what is believed to be 157 cannabis plants.
Police said the plants growing inside the home were seized during the operation as well as electrical equipment, which was taken to Nowra Police Station.
It is understood the haul included 80 seedlings and another 77 plants that ranged in size from 15 centimetres through to mature 1.5m plants.
It is believed a quantity, of what appears to be cannabis leaf, was also seized.
Forensic officers remained at the home until around 9.30pm, gathering evidence. An agronomist will be in Nowra on Tuesday afternoon to formally identify the plants.
No arrests were made following the seizure with police saying inquiries were ongoing.